Penn is open Thursday, Friday and Saturday. From RUH you would want to take College Drive West over the bridge. Take your first right off the bridge (Spadina) up to 33rd Street (I believe it's a 3 way stop, but it is a little bit of a distance up). Go down 33rd Street and you eventually get there. It will be on your right hand side of the street across from the Safeway. Hope this helps.